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Virulence profiling of Cryptococcus gattii isolates in China: insights from a multi-center study.

Microbiology spectrum - 12 Dec 2023

Zang Xuelei, Ke Weixin, Huang Yemei, Yang Chen, Song Jialin, Deng Hengyu, Zhou Meng, Wang Qiqi, Zhou Yangyu, Dai Bin, Qian Jin, Shen Dingxia, Wang Linqi, Xue Xinying

Abstract excerpt

IMPORTANCE: Our study indicates that the molecular typing of Cryptococcus gattii is unrelated to virulence. The integration of animal experiments and clinical prognosis demonstrated that pathogenicity did not exhibit a direct correlation with in vitro virulence phenotypes or molecular genotypes, emphasizing the intricate nature of virulence. In conclusion, our research holds the potential to provide valuable...

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Identifiers

PMID: 37905820
DOI: 10.1128/spectrum.02443-23
PMCID: PMC10714995

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