Article
Generation of human induced pluripotent stem cell line (MUi033-A) from a male with homozygous for Hemoglobin E.
Stem cell research - 1 Dec 2023
Tong-Ngam Pirut, Wongkummool Wasinee, Pongpaksupasin Phitchapa, Rawara Nongnaphat, Kovanich Duangnapa, Kitiyanant Narisorn, Munkongdee Thongperm, Paiboonsukwong Kittiphong, Fucharoen Suthat, Tubsuwan Alisa
Abstract excerpt
Hemoglobin E (HbE), a common variant in Southeast Asian populations, results from a G to A substitution at codon 26 of the HBB gene, causing abnormal Hb and mild β-thalassemia-like symptoms. Here, we derived an induced pluripotent stem cell (iPSC) line, named MUi033-A, from a male homozygous for HbE. The iPSC line demonstrates a normal karyotype and embryonic stem cell-like properties including pluripotency gene...
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