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Genetic Variations and Altered Blood mRNA Level of Circadian Genes and BDNF as Risk Factors of Post-Stroke Cognitive Impairment Among Eastern Indians.

Neuromolecular medicine - 1 Dec 2023

Sadhukhan Dipanwita, Biswas Arindam, Mishra Smriti, Chatterjee Koustav, Maji Daytee, Mitra Parama, Mukherjee Priyanka, Podder Gargi, Ray Biman Kanti, Biswas Atanu, Banerjee Tapas Kumar, Hui Subhra Prakash, Deb Ishani

Abstract excerpt

Post-stroke cognitive impairment (PSCI) is a clinical outcome in around 30% of post-stroke survivors. BDNF is a major gene in this regard. It is regulated by circadian rhythm. The circadian genes are correlated with stroke timings at molecular level. However, studies suggesting the role of these on susceptibility to PSCI are limited. We aim here to determine: (a) genetic risk variants in circadian clock genes,...

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PMID: 37814155
DOI: 10.1007/s12017-023-08761-2

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