Congenital defects among the offspring of epileptic fathers: role of the genotype and phenytoin therapy in a mouse model.

doi:10.1111/j.1528-1157.1986.tb03597.x

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Congenital defects among the offspring of epileptic fathers: role of the genotype and phenytoin therapy in a mouse model.

Epilepsia - 1 Jan 2000

Finnell R H, Baer J F

Abstract excerpt

The progeny of coisogenic C57BL/6J mice homozygous for either the tottering (tg/tg) or wildtype (+/+) allele were examined to determine the role of parental seizure disorders and paternal anticonvulsant drug therapy on the incidence of congenital malformations. Pregnancy outcomes in which one, both, or neither of the parents had an epileptic genotype were compared for various maternal and fetal reproductive...

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