Article
Human peripheral blood mononuclear cells display a temporal evolving inflammatory profile after myocardial infarction and modify myocardial fibroblasts phenotype.
Scientific reports - 5 Oct 2023
Miquelestorena-Standley Elodie, da Silva Ana Valéria Vinhais, Monnier Marina, Chadet Stéphanie, Piollet Marie, Héraud Audrey, Lemoine Roxane, Bochaton Thomas, Derumeaux Geneviève, Roger Sébastien, Ivanes Fabrice, Angoulvant Denis
Abstract excerpt
Pathophysiological response after acute myocardial infarction (AMI) is described as a three-stage model involving temporal phenotypic modifications of both immune cells and fibroblasts: a primary inflammatory phase, followed by a reparative phase and a fibrous scar maturation phase. Purinergic receptors, particularly the P2Y11 receptor, have been reported to be involved in the regulation of inflammation after...
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