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Integrative bioinformatics analysis and experimental validation of key biomarkers for risk stratification in primary biliary cholangitis

2 Oct 2023

Abstract excerpt

BACKGROUND: Primary biliary cholangitis (PBC) is an autoimmune liver disease, whose etiology is yet to be fully elucidated. Currently, ursodeoxycholic acid (UDCA) is the only first-line drug. However, 40% of PBC patients respond poorly to it and carry a potential risk of disease progression. So, in this study, we aimed to explore new biomarkers for risk stratification in PBC patients to enhance treatment....

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PMID: 37784152
DOI: 10.1186/s13075-023-03163-y

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