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Article

Targetable NOTCH1 rearrangements in reninoma

25 Sept 2023

Abstract excerpt

Reninomas are exceedingly rare renin-secreting kidney tumours that derive from juxtaglomerular cells, specialised smooth muscle cells that reside at the vascular inlet of glomeruli. They are the central component of the juxtaglomerular apparatus which controls systemic blood pressure through the secretion of renin. We assess somatic changes in reninoma and find structural variants that generate canonical...

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PMID: 37749094
DOI: 10.1038/s41467-023-41118-8

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