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Article

Prognostic impact of EGFR/ALK alterations in leptomeningeal metastasis from lung adenocarcinoma treated with whole-brain radiotherapy.

Clinical & experimental metastasis - 1 Oct 2023

Oyoshi Hidekazu, Hirata Hidenari, Hirano Yasuhiro, Zenda Sadamoto, Zhou Yuzheng, Tomizawa Kento, Fujisawa Takeshi, Nakamura Masaki, Hojo Hidehiro, Motegi Atsushi, Kageyama Shun-Ichiro, Zenke Yoshitaka, Goto Koichi, Ishihara Shunichi, Naganawa Shinji, Akimoto Tetsuo

Abstract excerpt

The prognosis and prognostic factors of patients receiving whole-brain radiotherapy (WBRT) for leptomeningeal metastasis (LM) from lung adenocarcinoma have not been established. Particularly, the impact of EGFR mutations and ALK rearrangements on survival remains unclear. This retrospective study evaluated the prognosis and prognostic factors of patients receiving WBRT for LM. We evaluated overall survival (OS)...

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PMID: 37468822
DOI: 10.1007/s10585-023-10225-7

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