Article
Elexacaftor-Tezacaftor-Ivacaftor Therapy for Chronic Sinus Disease in Cystic Fibrosis.
JAMA otolaryngology-- head & neck surgery - 1 Dec 2023
Sheikh Shahid, Ho Mai-Lan, Eisner Mariah, Gushue Courtney, Paul Grace, Holtzlander Melissa, Johnson Terri, McCoy Karen S, Lind Meredith
Abstract excerpt
Importance: Cystic fibrosis (CF) is a multiorgan genetic disease with progressive upper and lower airway involvement. The effects of CF transmembrane conductance regulator (CFTR) modifier therapies on CF-related upper airway disease, specifically chronic rhinosinusitis (CRS), are not characterized. Objective: To determine the outcome of elexacaftor-tezacaftor-ivacaftor (ETI) on CRS as measured by changes in sinus...
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