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Severe mental illness and the risk of breast cancer: A two-sample, two-step multivariable Mendelian randomization study

1 Sept 2023

Abstract excerpt

BACKGROUND: Based on epidemiological reports, severe mental illness (SMI) and breast cancer (BC) risk are linked positively. However, it is susceptible to clinical confounding factors, such as smoking, alcohol consumption, etc. Here, we performed a two-sample, two-step multivariable Mendelian randomization (MR) research to explore how the SMI etiologically influences BC risk and to quantify mediating effects of...

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PMID: 37656762
DOI: 10.1371/journal.pone.0291006

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