Article
A DNA adenine demethylase impairs PRC2-mediated repression of genes marked by a specific chromatin signature.
Genome biology - 30 Aug 2023
Jia Qingxiao, Zhang Xinran, Liu Qian, Li Junjie, Wang Wentao, Ma Xuan, Zhu Bo, Li Sheng, Gong Shicheng, Tian Jingjing, Yuan Meng, Zhao Yu, Zhou Dao-Xiu
Abstract excerpt
BACKGROUND: The Fe (II)- and α-ketoglutarate-dependent AlkB family dioxygenases are implicated in nucleotide demethylation. AlkB homolog1 (ALKBH1) is shown to demethylate DNA adenine methylation (6mA) preferentially from single-stranded or unpaired DNA, while its demethylase activity and function in the chromatin context are unclear. RESULTS: Here, we find that loss-of-function of the rice ALKBH1 gene leads to...
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