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A human monoclonal antibody combination rescues nonhuman primates from advanced disease caused by the major lineages of Lassa virus

17 Aug 2023

Abstract excerpt

There are no approved treatments for Lassa fever (LF), which is responsible for thousands of deaths each year in West Africa. A major challenge in developing effective medical countermeasures against LF is the high diversity of circulating Lassa virus (LASV) strains with four recognized lineages and four proposed lineages. The recent resurgence of LASV in Nigeria caused by genetically distinct strains underscores...

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PMID: 37590417
DOI: 10.1073/pnas.2304876120

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