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Article

The effect of lacosamide in peripheral neuropathic pain: A randomized, double-blind, placebo-controlled, phenotype-stratified trial.

European journal of pain (London, England) - 1 Jan 2024

Carmland Malin Erika, Kreutzfeldt Melissa Dall, Holbech Jakob Vormstrup, Brask-Thomsen Peter Kolind, Krøigård Thomas, Hansen Peter Nørregaard, Tankisi Hatice, Jensen Troels Staehelin, Bach Flemming Winther, Sindrup Søren Hein, Finnerup Nanna Brix

Abstract excerpt

BACKGROUND: Neuropathic pain is common and difficult to treat. The sodium channel blocker lacosamide is efficacious in animal models of pain, but its effect on neuropathic pain in humans is inconclusive. METHODS: In a multicentre, randomized, double-blinded placebo-controlled phenotype stratified trial, we examined if lacosamide produced better pain relief in patients with the irritable nociceptor phenotype...

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PMID: 37565715
DOI: 10.1002/ejp.2165

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