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Hsa_circ_0001946 Ameliorates Mechanical Stress-induced Intervertebral Disk Degeneration Via Targeting miR-432-5p and SOX9

9 Aug 2023

Abstract excerpt

STUDY DESIGN: Experimental analysis of circular RNA in intervertebral disk degeneration (IDD). OBJECTIVE: This study aimed to explore the roles of hsa_circ_0001946 (circ-CDR1as) in mechanical stress-induced nucleus pulposus cell injury in IDD. SUMMARY OF BACKGROUND DATA: Mechanical stress is an important pathogenic factor for IDD. Excessive compression stress leads to nucleus pulposus (NP) cell apoptosis and...

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PMID: 37555796
DOI: 10.1097/brs.0000000000004777

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