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Article

HRAS-mutated primary thyroid malignant melanoma or medullary thyroid carcinoma with melanocytic dedifferentiation? A singular case with an ontogeny-phylogeny quandary.

Virchows Archiv : an international journal of pathology - 1 Sept 2023

Subramanian Priyadarsani, Deshmukh Anuja, Kante Katha, Patil Asawari, Pai Trupti, Kaur Ramandeep, Rane Swapnil, Shetty Omshree, Ankathi Suman Kumar, Mittal Neha

Abstract excerpt

Melanotic pigment in the thyroid is practically synonymous with chronic minocycline therapy and rare cases of melanotic medullary thyroid carcinoma. However, primary melanoma of the thyroid has not been reported yet. We report a rare case of a 25-year-old male with a locally aggressive thyroid mass and distant metastases at presentation. Radiologically, a 8.3×7.6-cm nodule was identified in the right thyroid...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 37550582
DOI: 10.1007/s00428-023-03619-1

Genes

HRAS
S100P
SOX10
TTF1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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