Article
Cytogenetic findings in Polish patients with suspected Fanconi anemia.
Advances in clinical and experimental medicine : official organ Wroclaw Medical University - 1 Apr 2024
Repczyńska Anna, Jułga Katarzyna, Lorenc Andżelika, Skalska-Sadowska Jolanta, Wysocki Mariusz, Zaucha-Prażmo Agnieszka, Drabko Katarzyna, Bossowski Artur, Dembowska-Bagińska Bożena, Wachowiak Jacek, Buciński Adam, Haus Olga
Abstract excerpt
BACKGROUND: The high sensitivity of cells of Fanconi anemia (FA) patients to DNA cross-linking agents (clastogens), such as mitomycin C (MMC), was used as a screening tool in Polish children with clinical suspicion of FA. OBJECTIVES: The aim of the study was to compare chromosome fragility between 3 groups, namely non-FA, possible mosaic FA and FA patients. MATERIAL AND METHODS: The study included 100 children...
Topics
- Humans
- Fanconi Anemia
- Male
- Child
- Female
- Poland
- Child, Preschool
- Adolescent
- Mosaicism
- Infant
- Mitomycin