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Article

Mediator complex in neurological disease.

Life sciences - 15 Sept 2023

Schiano Concetta, Luongo Livio, Maione Sabatino, Napoli Claudio

Abstract excerpt

Neurological diseases, including traumatic brain injuries, stroke (haemorrhagic and ischemic), and inherent neurodegenerative diseases cause acquired disability in humans, representing a leading cause of death worldwide. The Mediator complex (MED) is a large, evolutionarily conserved multiprotein that facilities the interaction between transcription factors and RNA Polymerase II in eukaryotes. Some MED subunits...

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PMID: 37516429
DOI: 10.1016/j.lfs.2023.121986

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