Article
Intercorrelation of Molecular Biomarkers and Clinical Phenotype Measures in Fragile X Syndrome.
Cells - 24 Jul 2023
Aishworiya Ramkumar, Chi Mei-Hung, Zafarullah Marwa, Mendoza Guadalupe, Ponzini Matthew Dominic, Kim Kyoungmi, Biag Hazel Maridith Barlahan, Thurman Angela John, Abbeduto Leonard, Hessl David, Randol Jamie Leah, Bolduc Francois V, Jacquemont Sebastien, Lippé Sarah, Hagerman Paul, Hagerman Randi, Schneider Andrea, Tassone Flora
Abstract excerpt
This study contributes to a greater understanding of the utility of molecular biomarkers to identify clinical phenotypes of fragile X syndrome (FXS). Correlations of baseline clinical trial data (molecular measures-FMR1 mRNA, CYFIP1 mRNA, MMP9 and FMRP protein expression levels, nonverbal IQ, body mass index and weight, language level, NIH Toolbox, adaptive behavior rating, autism, and other mental health...
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