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Generation of three isogenic control lines from patient-derived iPSCs carrying bi-allelic ABCA4 variants underlying Stargardt disease.

Stem cell research - 1 Sept 2023

Karjosukarso Dyah W, Bukkems Femke, Duijkers Lonneke, Leijsten Nico, Collin Rob W J

Abstract excerpt

Stargardt disease, a progressive retinal disorder, is associated with bi-allelic variants in ABCA4. Employing the CRISPR/Cas9 approach, we generated isogenic control lines (RMCGENi005-A-1, RMCGENi018-A-1, RMCGENi017-A-1) for each of three induced pluripotent stem cell lines (RMCGENi005-A, RMCGENi018-A, RMCGENi017-A) derived from Stargardt patients carrying compound heterozygous ABCA4 variants. All of the...

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PMID: 37480818
DOI: 10.1016/j.scr.2023.103169

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