Article
Fecal virome transplantation is sufficient to alter fecal microbiota and drive lean and obese body phenotypes in mice.
Gut microbes - 1 Jan 2000
Borin Joshua M, Liu Roland, Wang Yanhan, Wu Tsung-Chin, Chopyk Jessica, Huang Lina, Kuo Peiting, Ghose Chandrabali, Meyer Justin R, Tu Xin M, Schnabl Bernd, Pride David T
Abstract excerpt
The gastrointestinal microbiome plays a significant role in modulating numerous host processes, including metabolism. Prior studies show that when mice receive fecal transplants from obese donors on high-fat diets (HFD) (even when recipient mice are fed normal diets after transplantation), they develop obese phenotypes, demonstrating the prominent role that gut microbiota play in determining lean and obese...
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