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Article

A multiplatform metabolomics approach for comprehensive analysis of GIST xenografts with various KIT mutations.

The Analyst - 7 Aug 2023

Macioszek Szymon, Dudzik Danuta, Biesemans Margot, Wozniak Agnieszka, Schöffski Patrick, Markuszewski Michal J

Abstract excerpt

Metabolites in biological matrices belong to diverse chemical groups, ranging from non-polar long-chain fatty acids to small polar molecules. The goal of untargeted metabolomic analysis is to measure the highest number of metabolites in the sample. Nevertheless, from an analytical point of view, no single technique can measure such a broad spectrum of analytes. Therefore, we selected a method based on GC-MS and...

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PMID: 37458061
DOI: 10.1039/d3an00599b

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