Article
There are three major Neisseria gonorrhoeae β-lactamase plasmid variants which are associated with specific lineages and carry distinct TEM alleles.
Microbial genomics - 1 Jul 2023
Elsener Tabea A, Jolley Keith A, Sanders Eduard, Maiden Martin C J, Cehovin Ana, Tang Christoph M
Abstract excerpt
Neisseria gonorrhoeae is a significant threat to global health with an estimated incidence of over 80 million cases each year and high levels of antimicrobial resistance. The gonococcal β-lactamase plasmid, pbla, carries the TEM β-lactamase, which requires only one or two amino acid changes to become an extended-spectrum β-lactamase (ESBL); this would render last resort treatments for gonorrhoea ineffective....
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