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Article

Exposures to perfluoroalkyl substances and asthma phenotypes in childhood: an investigation of the COPSAC2010 cohort.

EBioMedicine - 1 Aug 2023

Sevelsted Astrid, Pedersen Casper-Emil Tingskov, Gürdeniz Gözde, Rasmussen Morten Arendt, Schullehner Jörg, Sdougkou Kalliroi, Martin Jonathan W, Lasky-Su Jessica, Morin Andreanne, Ober Carole, Schoos Ann-Marie Malby, Stokholm Jakob, Bønnelykke Klaus, Chawes Bo, Bisgaard Hans

Abstract excerpt

BACKGROUND: Exposure to perfluoroalkyl substances may affect offspring immune development and thereby increase risk of childhood asthma, but the underlying mechanisms and asthma phenotype affected by such exposure is unknown. METHODS: In the Danish COPSAC2010 cohort of 738 unselected pregnant women and their children plasma PFOS and PFOA concentrations were semi-quantified by untargeted metabolomics analyses and...

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Identifiers

PMID: 37429082
DOI: 10.1016/j.ebiom.2023.104699
PMCID: PMC10339117

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