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Article

Mediation and moderation of genetic risk of obesity through eating behaviours in two UK cohorts.

International journal of epidemiology - 25 Dec 2023

Begum Shahina, Hinton Eleanor C, Toumpakari Zoi, Frayling Timothy M, Howe Laura, Johnson Laura, Lawrence Natalia

Abstract excerpt

BACKGROUND: The mechanisms underlying genetic predisposition to higher body mass index (BMI) remain unclear. METHODS: We hypothesized that the relationship between BMI-genetic risk score (BMI-GRS) and BMI was mediated via disinhibition, emotional eating and hunger, and moderated by flexible (but not rigid) restraint within two UK cohorts: the Genetics of Appetite Study (GATE) (n = 2101, 2010-16) and the Avon...

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Identifiers

PMID: 37410385
DOI: 10.1093/ije/dyad092
PMCID: PMC10749755

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