Early Clearance of Plasma Epidermal Growth Factor Receptor Mutations as a Predictor of Outcome on Osimertinib in Advanced Non-Small Cell Lung Cancer; Exploratory Analysis from AURA3 and FLAURA.

doi:10.1158/1078-0432.CCR-22-3146

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Article

Early Clearance of Plasma Epidermal Growth Factor Receptor Mutations as a Predictor of Outcome on Osimertinib in Advanced Non-Small Cell Lung Cancer; Exploratory Analysis from AURA3 and FLAURA.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Sept 2023

Gray Jhanelle E, Ahn Myung-Ju, Oxnard Geoffrey R, Shepherd Frances A, Imamura Fumio, Cheng Ying, Okamoto Isamu, Cho Byoung Chul, Lin Meng-Chih, Wu Yi-Long, Majem Margarita, Gautschi Oliver, Boyer Michael, Bulusu Krishna C, Markovets Aleksandra, Barrett J Carl, Hodge Rachel, McKeown Astrid, Hartmaier Ryan J, Chmielecki Juliann, Papadimitrakopoulou Vassiliki A, Ramalingam Suresh S

Abstract excerpt

PURPOSE: Plasma circulating tumor DNA (ctDNA) analysis is used for genotyping advanced non-small cell lung cancer (NSCLC); monitoring dynamic ctDNA changes may be used to predict outcomes. PATIENTS AND METHODS: This was a retrospective, exploratory analysis of two phase III trials [AURA3 (NCT02151981), FLAURA (NCT02296125)]. All patients had EGFR mutation-positive (EGFRm; ex19del or L858R) advanced NSCLC; AURA3...

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PMID: 37379430
DOI: 10.1158/1078-0432.CCR-22-3146

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