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Structural aging of human neurons is opposite of the changes in schizophrenia

23 Jun 2023

Abstract excerpt

Human mentality develops with age and is altered in psychiatric disorders, though their underlying mechanism is unknown. In this study, we analyzed nanometer-scale three-dimensional structures of brain tissues of the anterior cingulate cortex from eight schizophrenia and eight control cases. The distribution profiles of neurite curvature of the control cases showed a trend depending on their age, resulting in an...

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PMID: 37352288
DOI: 10.1371/journal.pone.0287646

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