Article
MAML3 Contributes to Induction of Malignant Phenotype of Gallbladder Cancer Through Morphogenesis Signalling Under Hypoxia.
Anticancer research - 1 Jul 2023
Na Lin, Onishi Hideya, Morisaki Shinji, Ichimiya Shu, Yamada Yutaka, Masuda Shogo, Nagao Shinjiro, Koga Satoko, Nakayama Kazunori, Imaizumi Akira, Oda Yoshinao, Nakamura Masafumi
Abstract excerpt
BACKGROUND/AIM: Hedgehog (HH) signalling is a potential therapeutic target for gallbladder cancer (GBC), and Mastermind-like 3 (MAML3) is involved in the transcription of Smoothened (SMO), which is a key protein of HH signalling during hypoxia in the cancer microenvironment. MAML3 is a NOTCH signalling activator, and HH and NOTCH are involved in morphogenesis signalling. However, the association between...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.