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Article

Susceptibility and disease modifier genes in amyotrophic lateral sclerosis: from genetic associations to therapeutic implications.

Current opinion in neurology - 1 Aug 2023

Willemse Sean W, van Es Michael A

Abstract excerpt

PURPOSE OF REVIEW: Amyotrophic lateral sclerosis (ALS) is a severe disease characterized by the degeneration of motor neurons. Large-scale genetic studies have now identified over 60 genes that are associated with ALS, which in large part have also been functionally characterized. The purpose of this review is to outline how these advances are being translated into novel therapeutic strategies. RECENT FINDINGS:...

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Identifiers

PMID: 37338820
DOI: 10.1097/WCO.0000000000001178
PMCID: PMC10328529

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