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Circular RNA circTRAPPC6B Enhances IL-6 and IL-1β Expression and Repolarizes Mycobacteria Induced Macrophages from M2- to M1-Like Phenotype by Targeting miR-892c-3p.

Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research - 1 Jun 2023

Peng Ying, Wu Xian-Jin, Ji Xue-Jiao, Huang Gui-Xian, Wu Tian, Liu Xi, Yang Rui, Pi Jiang, Shen Hong-Bo, Wang Fei-Fei, Xu Jun-Fa

Abstract excerpt

Mycobacterium tuberculosis (Mtb) infection elicits macrophage polarization into M2 phenotype to block the host's protective immune response. However, it remains unclear how Mtb regulates macrophage polarization. Recent studies have suggested that noncoding RNA may play a role in macrophage polarization. In this study, we investigated the potential involvement of circTRAPPC6B, a circular RNA that is downregulated...

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Identifiers

PMID: 37319356
DOI: 10.1089/jir.2023.0007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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