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Article

Influence of TPH2 and HTR1A polymorphisms on lifelong premature ejaculation risk among the chinese Han population.

BMC urology - 9 May 2023

Wang Fei, Luo Defan, Chen Jianxiang, Pan Cuiqing, Wang Zhongyao, Fu Housheng, Xu Jianbing, Yang Meng, Mo Shaowei, Zhuang Liying, Wang Weifu

Abstract excerpt

BACKGROUND: Lifelong premature ejaculation (LPE) is one of the most common ejaculatory dysfunctions in men. The serotonin (5-HT) synthesis rate-limiting enzyme (TPH2) and receptor (HTR1A) in the 5-HT regulatory system may play a key role in the pathogenesis of LPE. However, there are few studies on the effects of TPH2 and HTR1A polymorphisms on LPE risk. We speculated that TPH2 and HTR1A polymorphisms may affect...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Single Nucleotide

Share to Receptor, Serotonin, 5-HT1A

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Source

Open in PubMed Open full text

Identifiers

PMID: 37161455
DOI: 10.1186/s12894-023-01222-9
PMCID: PMC10170821

Genes

HTR1A
TPH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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