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Article

Discovery of imidazo[1,2-b]pyridazine macrocyclic derivatives as novel ALK inhibitors capable of combating multiple resistant mutants.

Bioorganic & medicinal chemistry letters - 1 Jun 2023

Xiao Xiaofei, Xu Yunsheng, Yu Xihua, Chen Yinbo, Zhao Weiwei, Xie Zhendong, Zhu Xueyan, Xu Hongjiang, Yang Yulei, Zhang Peng

Abstract excerpt

Anaplastic lymphoma kinase (ALK)-tyrosine kinase inhibitor (TKI) often loses effectiveness against non-small cell lung malignancies (NSCLCs) with ALK gene rearrangements (ALK+). 19 novel imidazo[1,2-b]pyridazine macrocyclic derivatives were designed, synthesized, and tested for their biological activities in an effort to develop ALK inhibitors that would overcome second-generation ALK-TKIs, particularly the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37127101
DOI: 10.1016/j.bmcl.2023.129309

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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