Article
Reversion of mutations in a live mycoplasma vaccine alters its metabolism.
Vaccine - 16 May 2023
Klose Sara M, De Souza David P, Disint Jillian F, Andrews Daniel M, Underwood Gregory J, Morrow Chris J, Marenda Marc S, Noormohammadi Amir H
Abstract excerpt
The live attenuated temperature sensitive vaccine strain MS-H (Vaxsafe® MS, Bioproperties Pty. Ltd., Australia) is widely used to control disease associated with M. synoviae infection in commercial poultry. MS-H was derived from a field strain (86079/7NS) through N-methyl-N'-nitro-N-nitrosoguanidine (NTG)-induced mutagenesis. Whole genomic sequence analysis of the MS-H and comparison with that of the 86079/7NS...
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