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Article

Unique Haplotypes in OPN1LW as a Common Cause of High Myopia With or Without Protanopia: A Potential Window Into Myopic Mechanism.

Investigative ophthalmology & visual science - 3 Apr 2023

Wang Yingwei, Sun Wenmin, Xiao Xueshan, Jiang Yi, Ouyang Jiamin, Wang Junwen, Yi Zhen, Li Shiqiang, Jia Xiaoyun, Wang Panfeng, Hejtmancik J Fielding, Zhang Qingjiong

Abstract excerpt

Purpose: Specific haplotypes (LVAVA, LIVVA, and LIAVA) formed by five polymorphisms (p.L153M, p.V171I, p.A174V, p.I178V, and p.S180A in exon 3 of OPN1LW) that cause partial or complete exon skipping have been reported as unique genetic causes of high myopia with or without colorblindness. This study aimed to identify the contribution of OPN1LW to early-onset high myopia (eoHM) and the molecular basis underlying...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37097228
DOI: 10.1167/iovs.64.4.29
PMCID: PMC10148663

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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