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Article

Disease-related p63 DBD mutations impair DNA binding by distinct mechanisms and varying degree.

Cell death & disease - 18 Apr 2023

Osterburg Christian, Ferniani Marco, Antonini Dario, Frombach Ann-Sophie, D'Auria Ludovica, Osterburg Susanne, Lotz Rebecca, Löhr Frank, Kehrloesser Sebastian, Zhou Huiqing, Missero Caterina, Dötsch Volker

Abstract excerpt

The transcription factor p63 shares a high sequence identity with the tumour suppressor p53 which manifests itself in high structural similarity and preference for DNA sequences. Mutations in the DNA binding domain (DBD) of p53 have been studied in great detail, enabling a general mechanism-based classification. In this study we provide a detailed investigation of all currently known mutations in the p63 DBD,...

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Identifiers

PMID: 37072394
DOI: 10.1038/s41419-023-05796-y
PMCID: PMC10113246

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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