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Article

On-person adaptive evolution of Staphylococcus aureus during treatment for atopic dermatitis.

Cell host & microbe - 12 Apr 2023

Key Felix M, Khadka Veda D, Romo-González Carolina, Blake Kimbria J, Deng Liwen, Lynn Tucker C, Lee Jean C, Chiu Isaac M, García-Romero Maria T, Lieberman Tami D

Abstract excerpt

The opportunistic pathogen Staphylococcus aureus frequently colonizes the inflamed skin of people with atopic dermatitis (AD) and worsens disease severity by promoting skin damage. Here, we show, by longitudinally tracking 23 children treated for AD, that S. aureus adapts via de novo mutations during colonization. Each patient's S. aureus population is dominated by a single lineage, with infrequent invasion by...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 37054679
DOI: 10.1016/j.chom.2023.03.009
PMCID: PMC10263175

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