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Maturity-onset Diabetes of the Young Type 7 (MODY7) and the Krüppellike Factor 11 Mutation (KLF11). A Review.

Current diabetes reviews - 1 Jan 2024

Mancera-Rincón Pedro, Luna-España Maria Camila, Rincon Oswaldo, Guzmán Issac, Alvarez Mauricio

Abstract excerpt

INTRODUCTION: Maturity-onset diabetes of the young (MODY) is a rare disease due to a single gene mutation that affects several family members in most cases. The Krüppel-like factor 11 (KLF11) gene mutation is associated with decreased insulin sensitivity to high glucose levels. KLF 11 has been implicated in the pathogenesis of MODY type 7 but given its low prevalence, prolonged subclinical period, and the...

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PMID: 36944622
DOI: 10.2174/1573399819666230321114456

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