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Article

Distribution and prognostic impact of EGFR and KRAS mutations according to histological subtype and tumor invasion status in pTis-3N0M0 lung adenocarcinoma.

BMC cancer - 14 Mar 2023

Ito Masaoki, Miyata Yoshihiro, Kushitani Kei, Ueda Daisuke, Takeshima Yukio, Okada Morihito

Abstract excerpt

BACKGROUND: The prognostic impact of EGFR mutation as major targetable somatic gene variant on lung adenocarcinoma is controversial. KRAS is another major somatic variant in lung adenocarcinoma, and a therapeutic agent for KRAS G12C became available in clinical settings. These mutations represent clinicopathological features of lung adenocarcinoma and can guide the treatment choice after recurrence. We evaluated...

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PMID: 36918771
DOI: 10.1186/s12885-023-10716-6
PMCID: PMC10015689

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Source receipt: pubmed, retrieved 7 Sept 2026.

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