Article
Distribution and prognostic impact of EGFR and KRAS mutations according to histological subtype and tumor invasion status in pTis-3N0M0 lung adenocarcinoma.
BMC cancer - 14 Mar 2023
Ito Masaoki, Miyata Yoshihiro, Kushitani Kei, Ueda Daisuke, Takeshima Yukio, Okada Morihito
Abstract excerpt
BACKGROUND: The prognostic impact of EGFR mutation as major targetable somatic gene variant on lung adenocarcinoma is controversial. KRAS is another major somatic variant in lung adenocarcinoma, and a therapeutic agent for KRAS G12C became available in clinical settings. These mutations represent clinicopathological features of lung adenocarcinoma and can guide the treatment choice after recurrence. We evaluated...
Topics
- Humans
- Female
- Prognosis
- Proto-Oncogene Proteins p21(ras)
- Neoplasm Staging
- Adenocarcinoma of Lung
- Lung Neoplasms
- Neoplastic Processes
- Mutation
- ErbB Receptors