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Article

Effect of BIM expression on the prognostic value of PD-L1 in advanced non-small cell lung cancer patients treated with EGFR-TKIs.

Scientific reports - 9 Mar 2023

Chu Chang-Yao, Lin Chien-Yu, Lin Chien-Chung, Li Chien-Feng, Wu Shang-Yin, Tsai Jeng-Shiuan, Yang Szu-Chun, Chen Chian-Wei, Lin Chia-Yin, Chang Chao-Chun, Yen Yi-Ting, Tseng Yau-Lin, Su Po-Lan, Su Wu-Chou

Abstract excerpt

The role of Programmed Cell Death Ligand 1 (PD-L1) expression in predicting epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKIs) efficacy remains controversial. Recent studies have highlighted that tumor-intrinsic PD-L1 signaling can be modulated by STAT3, AKT, MET oncogenic pathway, epithelial-mesenchymal transition, or BIM expression. This study aimed to investigate whether these underlying...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36894581
DOI: 10.1038/s41598-023-30565-4
PMCID: PMC9998621

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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