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Article

Clinical significance of epidermal growth factor receptor tyrosine kinase inhibitors: sensitivity and resistance.

Respiratory investigation - 1 Nov 2014

Takeuchi Shinji, Yano Seiji

Abstract excerpt

Gefitinib and erlotinib, which are epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (EGFR-TKIs), are highly effective against lung tumors with EGFR activating mutations. However, in 20-30% of cases, there is intrinsic resistance, and even if the treatment is effective, resistance is acquired in one to several years. Possible mechanisms of acquired resistance to EGFR-TKI, thus far, include a...

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Source

Identifiers

PMID: 25453378
DOI: 10.1016/j.resinv.2014.10.002

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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