Characterization of neurotropic HPAI H5N1 viruses with novel genome constellations and mammalian adaptive mutations in free-living mesocarnivores in Canada.

doi:10.1080/22221751.2023.2186608

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Characterization of neurotropic HPAI H5N1 viruses with novel genome constellations and mammalian adaptive mutations in free-living mesocarnivores in Canada.

Emerging microbes & infections - 1 Dec 2023

Alkie Tamiru N, Cox Sherri, Embury-Hyatt Carissa, Stevens Brian, Pople Neil, Pybus Margo J, Xu Wanhong, Hisanaga Tamiko, Suderman Matthew, Koziuk Janice, Kruczkiewicz Peter, Nguyen Hoang Hai, Fisher Mathew, Lung Oliver, Erdelyan Cassidy N G, Hochman Orie, Ojkic Davor, Yason Carmencita, Bravo-Araya Maria, Bourque Laura, Bollinger Trent K, Soos Catherine, Giacinti Jolene, Provencher Jennifer, Ogilvie Sarah, Clark Amanda, MacPhee Robyn, Parsons Glen J, Eaglesome Hazel, Gilbert Sayrah, Saboraki Kelsey, Davis Richard, Jerao Alexandra, Ginn Matthew, Jones Megan E B, Berhane Yohannes

Abstract excerpt

The GsGd lineage (A/goose/Guangdong/1/1996) H5N1 virus was introduced to Canada in 2021/2022 through the Atlantic and East Asia-Australasia/Pacific flyways by migratory birds. This was followed by unprecedented outbreaks affecting domestic and wild birds, with spillover into other animals. Here, we report sporadic cases of H5N1 in 40 free-living mesocarnivore species such as red foxes, striped skunks, and mink in...

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PMID: 36880345
DOI: 10.1080/22221751.2023.2186608
PMCID: PMC10026807

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