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Article

Bias in Gene-by-Environment Interaction Effects with Sum Scores; An Application to Well-being Phenotypes.

Behavior genetics - 1 Jul 2023

Pelt Dirk H M, Schwabe Inga, Bartels Meike

Abstract excerpt

In the current study, we investigated the influence of using skewed sum scores on estimated gene-by-environment interaction effects (GxE) for life satisfaction and happiness with perceived social support. To this end, we analyzed item-level data from a large adult twin sample (Ns between 3610 and 11,305) of the Netherlands Twin Register. Item response theory (IRT) models were incorporated in unmeasured...

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PMID: 36856918
DOI: 10.1007/s10519-023-10137-y
PMCID: PMC10275801

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