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Article

Why does the X chromosome lag behind autosomes in GWAS findings?

PLoS genetics - 1 Feb 2023

Gorlov Ivan P, Amos Christopher I

Abstract excerpt

The X-chromosome is among the largest human chromosomes. It differs from autosomes by a number of important features including hemizygosity in males, an almost complete inactivation of one copy in females, and unique patterns of recombination. We used data from the Catalog of Published Genome Wide Association Studies to compare densities of the GWAS-detected SNPs on the X-chromosome and autosomes. The density of...

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PMID: 36848382
DOI: 10.1371/journal.pgen.1010472
PMCID: PMC9997976

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