Article
Statistics for X-chromosome associations.
Genetic epidemiology - 1 Sept 2018
Özbek Umut, Lin Hui-Min, Lin Yan, Weeks Daniel E, Chen Wei, Shaffer John R, Purcell Shaun M, Feingold Eleanor
Abstract excerpt
In a genome-wide association study (GWAS), association between genotype and phenotype at autosomal loci is generally tested by regression models. However, X-chromosome data are often excluded from published analyses of autosomes because of the difference between males and females in number of X chromosomes. Failure to analyze X-chromosome data at all is obviously less than ideal, and can lead to missed...
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