Article
Intracellular Delivery of Anti-Kirsten Rat Sarcoma Antibodies Mediated by Polymeric Micelles Exerts Strong In Vitro and In Vivo Anti-Tumorigenic Activity in Kirsten Rat Sarcoma-Mutated Cancers.
ACS applied materials & interfaces - 1 Mar 2023
Rafael Diana, Montero Sara, Carcavilla Pilar, Andrade Fernanda, German-Cortés Júlia, Diaz-Riascos Zamira V, Seras-Franzoso Joaquin, Llaguno Monserrat, Fernández Begoña, Pereira Alfredo, Duran-Lara Esteban F, Schwartz Simó, Abasolo Ibane
Abstract excerpt
The Kirsten rat sarcoma viral oncogene (KRAS) is one of the most well-known proto-oncogenes, frequently mutated in pancreatic and colorectal cancers, among others. We hypothesized that the intracellular delivery of anti-KRAS antibodies (KRAS-Ab) with biodegradable polymeric micelles (PM) would block the overactivation of the KRAS-associated cascades and revert the effect of its mutation. To this end,...
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