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Meta-analysis of the prognostic impact of TP53 co-mutations in EGFR-mutant advanced non-small-cell lung cancer treated with tyrosine kinase inhibitors.

Critical reviews in oncology/hematology - 1 Apr 2023

Ferrara Miriam Grazia, Belluomini Lorenzo, Smimmo Annafrancesca, Sposito Marco, Avancini Alice, Giannarelli Diana, Milella Michele, Pilotto Sara, Bria Emilio

Abstract excerpt

PURPOSE: To assess the prognostic impact of TP53 mutations in EGFR-mutant advanced NSCLC patients treated with TKIs. METHODS: Studies exploring the clinical outcomes of EGFR mutant/TP53 wild-type versus EGFR/TP53 co-mutant patients treated with TKIs were selected. Data were cumulated by adopting a fixed and random-effect model. RESULTS: Overall, 29 trials were eligible. The PFS analysis showed that TP53 co-mutant...

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Identifiers

PMID: 36773668
DOI: 10.1016/j.critrevonc.2023.103929

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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