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Bioinformatics analyses of combined databases identify shared differentially expressed genes in cancer and autoimmune disease

10 Feb 2023

Abstract excerpt

BACKGROUND: Inadequate immunity caused by poor immune surveillance leads to tumorigenesis, while excessive immunity due to breakdown of immune tolerance causes autoimmune genesis. Although the function of immunity during the onset of these two processes appears to be distinct, the underlying mechanism is shared. To date, gene expression data for large bodies of clinical samples are available, but the resemblances...

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PMID: 36765396
DOI: 10.1186/s12967-023-03943-9

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