Article
Toward model-informed precision dosing for tamoxifen: A population-pharmacokinetic model with a continuous CYP2D6 activity scale.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie - 1 Apr 2023
Agema Bram C, Buijs Sanne M, Sassen Sebastiaan D T, Mürdter Thomas E, Schwab Mathias, Koch Birgit C P, Jager Agnes, van Schaik Ron H N, Mathijssen Ron H J, Koolen Stijn L W
Abstract excerpt
BACKGROUND: Tamoxifen is important in the adjuvant treatment of breast cancer. A plasma concentration of the active metabolite endoxifen of > 16 nM is associated with a lower risk of breast cancer-recurrence. Since inter-individual variability is high and > 20 % of patients do not reach endoxifen levels > 16 nM with the standard dose tamoxifen, therapeutic drug monitoring is advised. However, ideally, the correct...
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