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Picornavirus infection enhances aspartate by the SLC38A8 transporter to promote viral replication

3 Feb 2023

Abstract excerpt

Foot-and-mouth disease, a class of animal diseases, is caused by foot-and-mouth disease virus (FMDV). The metabolic changes during FMDV infection remain unclear. Here, PK-15 cells, serum, and tonsils infected with FMDV were analyzed by metabolomics. A total of 284 metabolites in cells were significantly changed after FMDV infection, and most of them belong to amino acids and nucleotides. Further studies showed...

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PMID: 36735752
DOI: 10.1371/journal.ppat.1011126

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