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Lappaol F regulates the cell cycle by activating CDKN1C/p57 in human colorectal cancer cells

28 Jan 2023

Abstract excerpt

Context Lappaol F (LAF), a natural lignan from Arctium lappa Linné (Asteraceae), inhibits tumor cell growth in vitro and in vivo. The underlying mechanism involves the suppression of the Yes-associated protein. However, the specific role of LAF in cell cycle regulation remains unknown.Objective This study determined the molecular mechanism by which LAF regulates cell cycle progression.Materials and methods...

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PMID: 36708218
DOI: 10.1080/13880209.2023.2172048

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