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Anlotinib combined with osimertinib reverses acquired osimertinib resistance in NSCLC by targeting the c-MET/MYC/AXL axis.

Pharmacological research - 1 Feb 2023

Lei Tianyao, Xu Tianwei, Zhang Niu, Zou Xiaoteng, Kong Ziyue, Wei Chenchen, Wang Zhaoxia

Abstract excerpt

Favorable clinical evidence suggests that the next trend in new treatments for advanced non-small cell lung cancer (NSCLC) will be combination therapies. However, inevitable epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) resistance greatly limits the clinical efficacy of patients carrying EGFR-activating mutants. In this study, we found a patient with clinical osimertinib resistance who...

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Identifiers

PMID: 36681369
DOI: 10.1016/j.phrs.2023.106668

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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Anlotinib combined with osimertinib reverses acquired osimertinib resistance in NSCLC by targeting the c-MET/MYC/AXL axis.PMID 36681369Read ↗

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